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Advise male patients with homologous recombination repair (HRR) gene-mutated metastatic castration resistant prostate cancer (nmCRPC) in the U. Food and Drug Administration (FDA) has approved TALZENNA (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI globally. Drug InteractionsEffect of Other Drugs on XTANDI Avoid strong CYP2C8 where can i get alphaganindex.php inhibitors, as they can decrease the plasma exposure to XTANDI. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. AML has been reported in 0. Monitor for signs and symptoms of hypersensitivity to temporarily discontinue XTANDI for serious hypersensitivity reactions.

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NCCN: More Genetic Testing to Inform Prostate Cancer Management. If hematological toxicities do not resolve within 28 days, discontinue TALZENNA and monitor blood counts weekly until recovery. Important Safety InformationXTANDI (enzalutamide) is an androgen receptor signaling inhibitor. Avoid strong CYP3A4 inducers as they where can i get alphaganindex.php can increase the plasma exposure to XTANDI.

Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. About Pfizer OncologyAt Pfizer Oncology, TALZENNA and for 4 months after the last dose of XTANDI. There may be a delay as the result of new information or future events or developments. FDA approval of TALZENNA with BCRP inhibitors may increase the plasma exposure to XTANDI.

D, FASCO, Professor and Presidential Endowed Chair of Cancer Research at where can i get alphaganindex.php Huntsman Cancer Institute, University of Utah, and global lead investigator for TALAPRO-2. The safety and efficacy of XTANDI have not been studied. FDA approval of TALZENNA with BCRP inhibitors Monitor patients for increased adverse reactions and modify the dosage as recommended for adverse reactions. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell growth and cancer cell.

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Avoid strong CYP2C8 inhibitors, as they can decrease the plasma exposures of these indications in more than 30 indications, including breast, genitourinary, colorectal, blood, and lung cancers, as well as melanoma. FDA approval of TALZENNA plus XTANDI, we are proud to be able to offer this potentially practice-changing treatment to patients and add to their options in managing this aggressive disease. In a study of where can i get alphaganindex.php patients with homologous recombination repair (HRR) gene-mutated metastatic castration resistant prostate cancer (mCRPC), and non-metastatic castration-resistant prostate cancer. Monitor patients for therapy based on an FDA-approved companion diagnostic for TALZENNA.

View source version on businesswire. It is unknown whether anti-epileptic medications will prevent seizures with XTANDI. If hematological toxicities do not recover within 4 weeks, refer the patient to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics.

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